Blar i forfatter "Thode, Sunniva Katharina"

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    • Construction of a fur null mutant and RNA-sequencing provide deeper global understanding of the Aliivibrio salmonicida Fur regulon 

      Thode, Sunniva Katharina; Bækkedal, Cecilie; Söderberg, Jenny Johansson; Hjerde, Erik; Hansen, Hilde; Haugen, Peik (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-13)
      <i>Background:</i> The ferric uptake regulator (Fur) is a transcription factor and the main regulator of iron acquisition in prokaryotes. When bound to ferric iron, Fur recognizes its DNA binding site and generally executes its function by repressing transcription of its target genes. Due to its importance in virulence, the Fur regulon is well studied for several model bacteria. In our previous ...

    • Distribution of siderophore gene systems on a Vibrionaceae phylogeny: Database searches, phylogenetic analyses and evolutionary perspectives 

      Thode, Sunniva Katharina; Rojek, Ewelina; Kozlowski, Mikolaj; Ahmad, Rafi; Haugen, Peik (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-14)
      Siderophores are small molecules synthesized and secreted by bacteria and fungi to scavenge iron. Extracellular ferri-siderohores are recognized by cognate receptors on the cell surface for transport over membranes. Several siderophore systems from <i>Vibrionaceae</i> representatives are known and well understood, e.g., the molecular structure of the siderophore, the biosynthesis gene cluster ...

    • The immediate global responses of Aliivibrio salmonicida to iron limitations 

      Thode, Sunniva Katharina; Kahlke, Tim; Robertsen, Espen Mikal; Hansen, Hilde; Haugen, Peik (Journal article; Tidsskriftartikkel, 2015-02-04)
      <i>Background</i>: Iron is an essential micronutrient for all living organisms, and virulence and sequestration of iron in pathogenic bacteria are believed to be correlated. As a defence mechanism, potential hosts therefore keep the level of free iron inside the body to a minimum. In general, iron metabolism is well studied for some bacteria (mostly human or animal pathogens). However, this area ...

    • Iron dependent gene regulation and siderophore systems in Vibrionaceae 

      Thode, Sunniva Katharina (Doctoral thesis; Doktorgradsavhandling, 2017-03-15)
      Bacteria live in fluctuating environments, which they sense and respond to through gene regulation. Availably of iron is an example of an element fluctuating and that can Bacteria sense.Iron is an essential micronutrient that is scares in several environments, especially in a host. The ferric uptake regulator, Fur, is the major iron level sensing protein and regulator of iron acquisition systems in ...